C Elegans Vulval Dev
The anchor cell is a cell in nematodes such as Caenorhabditis elegans. It is important in the development of the reproductive system, as it is required for the production of the tube of cells that allows embryos to pass from the uterus through the vulva to the outside of the worm. Best auto tune software for android.
Sep 16, 2018 The vulva is a part of female sex organ that consist of 22 cells and serves as a structure through which the sperm enter and fertilized eggs leaves the gonads.Vulva development in C. Vulval development in the nematode Caenorhabditis elegans is a beautifully simple system for asking how cells choose between different possible fates. Vulval fate patterning involves just seven cells: a signaling cell (the anchor cell), which initiates vulval fate induction, and six vulval precursor cells which can respond to that inductive signal by generating vulval descendants ( Figure 1 ). Elegans, Vulval development, Developmental timing, Gene expression Background For over 30 years, the vulval development of C. Elegans has been an important model in which to study mecha-nisms underlying the development of complex organ-isms 1, 2. However, most studies of vulval development. Jun 12, 2015 During the fourth larval (L4) stage, vulval cells of C. Elegans undergo extensive morphogenesis accompanied by changes in gene expression. This phase of vulval development, occurring after the well-studied induction of vulval cells, is not well understood but is potentially a useful context in which to study how a complex temporal sequence of events is regulated during development. Elegans Vulval Development: Induction at single cell resolution 1 2 3 4 5 6 7 8 9 10 11 12 The worm is born with 12 ectodermal ‘P cells’ along the ventral midline of the body. Anterior Posterior C. Elegans L1 larva hatchling 1 2 3 4 5 6 7 8 9 10 11 12 Each ectodermal P cell divides once to form a neuroblast and an epidermoblast. Anterior Posterior P.n Pn.a Pn.p. Movement of wild-type C. Elegans is unsegmented, vermiform, and bilaterally symmetrical. It has a cuticle (a tough outer covering, as an exoskeleton), four main epidermal cords, and a fluid-filled pseudocoelom (body cavity). It also has some of the same organ systems as larger animals.
During the development of C. eleganshermaphrodites, the anchor cell produces a signalling molecule (LIN-3/EGF) that induces nearby epidermal cells to develop into the vulva.[1] The anchor cell also produces another signal (the Notch ligand LAG-2) that induces adjacent uterine cells to become the π cells,[2] some of which will later connect the uterus to the vulva.[3] The anchor cell next removes the basement membrane that separates the uterus and vulva and invades, initiating the connection between the uterus and the vulva.[4] Finally the anchor cell fuses with eight of the π cells to form the uterine seam cell.[3]
References[edit]
- ^Hill RJ, Sternberg PW (August 1992). 'The gene lin-3 encodes an inductive signal for vulval development in C. elegans'. Nature. 358 (6386): 470–6. doi:10.1038/358470a0. PMID1641037.
- ^Newman AP, White JG, Sternberg PW (February 1995). 'The Caenorhabditis elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell'. Development. 121 (2): 263–71. PMID7768171.
- ^ abNewman AP, White JG, Sternberg PW (November 1996). 'Morphogenesis of the C. elegans hermaphrodite uterus'. Development. 122 (11): 3617–26. PMID8951077.
- ^Sherwood DR, Sternberg PW (July 2003). 'Anchor cell invasion into the vulval epithelium in C. elegans'. Dev. Cell. 5 (1): 21–31. doi:10.1016/S1534-5807(03)00168-0. PMID12852849.
External links[edit]
C Elegans Vulval Dev Test
- Anchor cell page at Wormbase – part of the anatomy ontology of C. elegans.